X-linked adreno leukodistrophy: Profiles of very long chain fatty acids in plasma and fibroblasts in eigth Serbian patients
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چکیده
منابع مشابه
Profiles of very-long-chain fatty acids in plasma, fibroblasts, and blood cells in Zellweger syndrome, X-linked adrenoleukodystrophy, and rhizomelic chondrodysplasia punctata.
Profiles of saturated very-long-chain (> C22) fatty acids were studied in plasma, fibroblasts, erythrocytes, platelets, and leukocytes of patients affected by peroxisomal disorders such as Zellweger syndrome, X-linked adrenoleukodystrophy (X-ALD), and classic rhizomelic chondrodysplasia punctata (RCDP) and in controls. In Zellweger patients, the concentration of hexacosanoic acid (C26:0) and th...
متن کاملX-linked adrenoleukodystrophy with non-diagnostic plasma very long chain fatty acids.
Measurement of plasma very long chain fatty acids is widely recognised as a sensitive screening test for X-linked adrenoleukodystrophy (X-ALD). This test has particular importance because of the highly variable clinical expression of X-ALD. In this affected family the progressive childhood form of X-ALD was accompanied by "non-diagnostic" concentrations of plasma very long chain fatty acids. Th...
متن کاملThe role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy
X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene encoding the peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP). X-ALD is characterized by the accumulation of very long-chain fatty acids (VLCFA; > or =C24) in plasma and tissues. In this manuscript we provide insight into the pathway underlying the elevated levels of C26:0 in X-ALD. ALDP transports VLC...
متن کاملMicrodetermination of long-chain fatty acids in plasma and tissues.
The ternary mixture, heptane-isopropyl alcohol-water, provides a convenient two-phase system for extraction of longchain fatty acids (1). When the solvent components are taken in suitable proportions, the phases separate rapidly without centrifugation. The long-chain fatty acids distribute predominantly into the upper, nonpolar phnsc, whereas the more polar acids remain below. This method of ex...
متن کاملOmega-oxidation of very long-chain fatty acids in human liver microsomes. Implications for X-linked adrenoleukodystrophy.
X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). Excess levels of VLCFAs are thought to play an important role in the pathogenesis of X-ALD. Therefore, therapeutic approaches for X-ALD are focused on the reduction or normalization of VLCFAs. In this study, we investigated an altern...
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ژورنال
عنوان ژورنال: Indian Journal of Clinical Biochemistry
سال: 2007
ISSN: 0970-1915,0974-0422
DOI: 10.1007/bf02913328